Is there a local renin-angiotensin system in the heart?

  title={Is there a local renin-angiotensin system in the heart?},
  author={Alexander Hj Danser and Jasper J Saris and Martin P. Schuijt and Jorge P. van Kats},
  journal={Cardiovascular research},
  volume={44 2},
The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes… CONTINUE READING
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