Is there a graft-versus-leukaemia effect in the absence of graft-versus-host disease in patients undergoing bone marrow transplantation for acute leukaemia?

@article{Ringdn2000IsTA,
  title={Is there a graft-versus-leukaemia effect in the absence of graft-versus-host disease in patients undergoing bone marrow transplantation for acute leukaemia?},
  author={Olle Ringd{\'e}n and Myriam Labopin and N. C. Gorin and Norbert Schmitz and Ulrich Wilhelm Schaefer and Hugh Grant Prentice and Lothar Bergmann and Jean Pierre Jouet and Franco Mandelli and Didier Blaise and Loic Fouillard and Francesco Frassoni},
  journal={British journal of haematology},
  year={2000},
  volume={111 4},
  pages={1130-7}
}
During a 13-year period, 5200 autografts, 1039 HLA-identical sibling transplants without acute or chronic graft-vs.-host disease (GVHD) and 67 twins were reported to the European Group for Blood and Marrow Transplantation EBMT. Follow-up time was a median of 32 months. Diagnoses were acute myeloid leukaemia (AML, 4521) and acute lymphoblastic leukaemia (ALL, 1785) in first complete remission. The probability of relapse at 5 years was 51 +/- 1% in the autografts, 45 +/- 8% in the twins and 34… CONTINUE READING

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