Is there a future for prenyltransferase inhibitors in cancer therapy?

@article{Holstein2012IsTA,
  title={Is there a future for prenyltransferase inhibitors in cancer therapy?},
  author={Sarah A. Holstein and Raymond J. Hohl},
  journal={Current opinion in pharmacology},
  year={2012},
  volume={12 6},
  pages={704-9}
}
It has been over 20 years since it was first recognized that the function of both normal and oncogenic Ras is dependent on the post-translational modification termed farnesylation. Since that time, intense effort has been expended on the development of farnesyltransferase inhibitors as novel anticancer agents. Over 70 clinical trials have now been conducted, with limited efficacy demonstrated. Here we provide an update of the most recently published clinical trials, discuss the use of the… CONTINUE READING