Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders?

@article{Griebel1999IsTA,
  title={Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders?},
  author={Guy Griebel},
  journal={Pharmacology & therapeutics},
  year={1999},
  volume={82 1},
  pages={1-61}
}
  • Guy Griebel
  • Published 1999 in Pharmacology & therapeutics
This review provides an overview of preclinical and clinical evidence of a role for the neuroactive peptides cholecystokinin (CCK), corticotropin-releasing factor (CRF), neuropeptide Y (NPY), tachykinins (i.e., substance P, neurokinin [NK] A and B), and natriuretic peptides in anxiety and/or stress-related disorders. Results obtained with CCK receptor antagonists in animal studies have been highly variable, and clinical trials with several of these compounds in anxiety disorders have been… CONTINUE READING

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