Is there a clinical association of vancomycin MIC creep, agr group II locus, and treatment failure in MRSA bacteremia?

@article{Sanctis2011IsTA,
  title={Is there a clinical association of vancomycin MIC creep, agr group II locus, and treatment failure in MRSA bacteremia?},
  author={Jorgelina de Sanctis and Aditi Swami and Kara E. Sawarynski and Ludmyla Gerasymchuk and Kim L. Powell and Barbara Robinson-Dunn and Christopher F. Carpenter and Matthew D Sims},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2011},
  volume={20 3},
  pages={184-8}
}
BACKGROUND The association of vancomycin treatment failure with minimum inhibitory concentration (MIC) creep is concerning, as most isolates are still considered to be in the susceptible range. Several studies have suggested that the accessory gene regulator (agr) group II polymorphism is predictive of vancomycin treatment failure. We assessed the associations between increased vancomycin MIC, agr group II locus, and vancomycin treatment failure in Methicillin-resistant Staphylococcus aureus… CONTINUE READING