Is there a basis for distinguishing two types of P2-purinoceptor?

@article{Burnstock1985IsTA,
  title={Is there a basis for distinguishing two types of P2-purinoceptor?},
  author={Geoffrey Burnstock and Charles Kennedy},
  journal={General pharmacology},
  year={1985},
  volume={16 5},
  pages={433-40}
}
It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagonists at the P2-purinoceptor: Subtype 1 (designated P2X), potency order: alpha, beta-methyleneATP, beta, gamma-methyleneATP greater than ATP = 2 methylthioATP; antagonism by ANAPP3 and selectively desensitisation following administration of alpha, beta-methyleneATP; present in the vas deferens and… CONTINUE READING
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