Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

@article{Kastner1992IsTV,
  title={Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?},
  author={Anne Kastner and Etienne C. Hirsch and Olivier Lejeune and France Javoy-Agid and Olivier Rascol and Yves Agid},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 3},
  pages={
          1080-9
        }
}
The contribution of neuromelanin (NM) to the pathogenesis of Parkinson's disease (PD) has long been suspected. In particular, a correlation has been reported between the estimated cell loss in the mesencephalic dopaminergic cell groups and the percentage of NM-pigmented neurons in these cell groups. To test whether the amount of pigment per cell is a critical factor or whether the presence of NM within a neuron is sufficient to account for the degeneration of dopaminergic neurons, the NM… CONTINUE READING

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