Is the use of IV pantoprazole appropriate in the critical care setting?

Abstract

and in the evaluation of disease management programs to capture the full impact of disease on patients’ lives. The purpose of this study was to evaluate the psychometric properties of the Treatment Satisfaction Questionnaire-Crohn’s (TSQ-C). Methods: The 36-item questionnaire was validated in CD patients treated with 5-aminosalicylic acid derivatives. Measures used in the validation process were the Inflammatory Bowel Disease Questionnaire (IBDQ), Crohn’s Work and Activity Impairment Index (CWAII), and patient-reports of clinical parameters. Exploratory factor analysis was used to evaluate the items and subscale structure. Cronbach’s alpha, Pearson correlation coefficient, and Analysis of Variance were used to evaluate internal consistency, reliability, and construct validity. Results: The 813 CD patients participating in the study were mostly Caucasian (95.9%), female (67.0%), and 35 years of age or older (86.1%). Patient-rated CD severity was mild to moderate (91.0%) and severe (7.5%). The final TSQ-C consisted of 32 items with 6 subscales (Symptoms, Satisfaction, Expectations, Physician Relationships, Bother, and Cost). Cronbach’s alphas ranged from 0.63 (Cost) to 0.94 (Symptoms). Strong correlations were observed between all measures used in the validation process: Satisfaction and Symptoms subscales, IBDQ, CWAII, and the clinical parameters. The Satisfaction and Symptoms subscales significantly discriminated among number of flares per year, patient-reported disease severity, and number of medication classes. Item analysis, using a 6-point Likert scale, revealed that “patients do not get immediate relief from their medication,”(56.3%)” feel they need additional medication to obtain complete relief,” (42%) “need to take their medication too many times a day to obtain relief, “(31.3%) and “worry about long-term use of their medication”(65.9%). Conclusions: The TSQ-C demonstrated excellent validity and reliability and can be a useful tool for evaluating satisfaction with pharmacologic therapy in patients with CD. Future research is needed on the responsiveness of this scale.

DOI: 10.1111/j.1572-0241.2003.08446.x

Cite this paper

@article{Mian2003IsTU, title={Is the use of IV pantoprazole appropriate in the critical care setting?}, author={Naima A Mian and Kevin T. White and LaRusso Michele and Kao Emily and Hirsch Bruce and Mullin E Gerard}, journal={American Journal of Gastroenterology}, year={2003}, volume={98}, pages={S234-S234} }