Is the tissue persistence of O(6)-methyl-2'-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?

@article{Tan2011IsTT,
  title={Is the tissue persistence of O(6)-methyl-2'-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?},
  author={Shir Ley Tan and Jacobus Petrus Gerber and Leah J. Cosgrove and Trevor J. Lockett and Julie M. Clarke and Desmond B. Williams and Richard J. Head},
  journal={Mutation research},
  year={2011},
  volume={721 2},
  pages={119-26}
}
Azoxymethane (AOM) is a methylating agent capable of inducing mutations in DNA by forming adducts with DNA bases. It has been used to understand the mechanisms involved in colon carcinogenesis. Of the adducts formed in response to AOM, O(6)-methyl-2'-deoxy-guanosine (O(6)-mdGua) is the most mutagenic. Based on studies in rodents of the abundance and persistence of DNA adducts in various tissues after treatment with alkylating agents, previous results suggest, as a generalization, that the… CONTINUE READING
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