Is the presence of sleep apnoea-hypopnoea syndrome a precursor for gout?

@article{Marinchev2013IsTP,
  title={Is the presence of sleep apnoea-hypopnoea syndrome a precursor for gout?},
  author={Lyubomir Marinchev},
  journal={Rheumatology},
  year={2013},
  volume={52 9},
  pages={
          1547-8
        }
}
Sleep apnoea hypopnoea syndrome (SAHS) is characterized by periodic apnoea that is associated with cyclical changes in arterial oxygen saturation (SaO2). In SAHS, Hasday and Grum [1] were the first to measure the overnight change of urinary uric acid secretion and report that it could be a good index of tissue hypoxia. However, the validation of this index has not been confirmed by subsequent studies [2], as this index remained normal in some patients with SAHS who had severe nocturnal arterial… 
Serum urate and obstructive sleep apnoea in severe obesity
TLDR
Serum urate is associated with OSA in severely obese females and CPAP may reduce levels in patients with O SA, and there may be a need to consider and assess for Osa in obese patients with hyperuricaemia and recurrent attacks of gout.
The assessment and characterisation of obstructive sleep apnoea in severe obesity
TLDR
The urinary proteomic studies identified trends in the urinary peptide profiles suggesting that there may be inherent differences between OSA and non-OSA patients, even following a period of effective CPAP treatment, as well as exploring the use of urinary proteomics in characterising subjects with severe obesity and OSA.

References

SHOWING 1-10 OF 12 REFERENCES
Tissue hypoxia in sleep apnea syndrome assessed by uric acid and adenosine.
TLDR
DeltaUA/Cr is a marker of tissue hypoxia, which does not necessarily parallel arterial desaturation indexes in OSAS, and intersubject variability in the HR response to apnea may explain the discrepancy between tissue Hypoxia and arterial Desaturation indexes.
Gout, hyperuricaemia, sleep apnoea–hypopnoea syndrome and vascular risk
TLDR
These patients had more severe forms of SAHS and a greater prevalence of documented atherothrombotic disease compared with a control group of subjects with knee OA and SAHS.
Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia.
TLDR
It is reported that urinary UA:Cr ratio increased overnight in a nonhomogeneous group of patients with sleep-associated hypoxemia, a convenient method for estimating uric uric acid excretion.
Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia.
TLDR
It is reported that urinary UA:Cr ratio increased overnight in a nonhomogeneous group of patients with sleep-associated hypoxemia, a convenient method for estimating uric uric acid excretion.
Overnight urinary uric acid: creatinine ratio for detection of sleep hypoxemia. Validation study in chronic obstructive pulmonary disease and obstructive sleep apnea before and after treatment with nasal continuous positive airway pressure.
TLDR
It is concluded that delta UA:Cr seems to be a promising index of significant nocturnal tissue hypoxia, with good specificity but poor sensitivity, which might be useful for the long-term follow-up of outpatients on nasal CPAP with a positive ratio at baseline.
Epidemiology of obstructive sleep apnea: a population health perspective.
TLDR
Evidence from methodologically strong cohort studies indicates that undiagnosed obstructive sleep apnea, with or without symptoms, is independently associated with increased likelihood of hypertension, cardiovascular disease, stroke, daytime sleepiness, motor vehicle accidents, and diminished quality of life.
Association between Serum Uric Acid Levels and Sleep Variables: Results from the National Health and Nutrition Survey 2005–2008
TLDR
A positive relationship between sleep variables, including the presence of snoring, snorting, and daytime sleepiness, and high serum uric acid levels is indicated.
Clinical patterns of obstructive sleep apnea and its comorbid conditions: a data mining approach.
TLDR
The data mining technique confirms the prevalence of the disease, describes the age distribution patterns and time courses of disease development from obesity and OSA to comorbid conditions, and implicates possible interrelationships among these conditions and high cost of treating OSA patients.
Dipyridamole inhibition of adenosine metabolism in human blood.
  • R. Klabunde
  • Biology, Medicine
    European journal of pharmacology
  • 1983
Turnover of adenosine in plasma of human and dog blood.
TLDR
Changes in plasma adenosine did not correlate well with changes in blood flow but were augmented in the presence of dipyridamole, and the decrease in specific radioactivity of added [3H]adenosine was measured using a dipyrIDamole-containing stopping solution.
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