Is the polarity of relapse/recurrence in bipolar-I disorder patients related to serum lithium levels? Results from an empirical study.

@article{Severus2009IsTP,
  title={Is the polarity of relapse/recurrence in bipolar-I disorder patients related to serum lithium levels? Results from an empirical study.},
  author={Wolfram Emanuel Severus and Nikolaus Kleindienst and Gary Evoniuk and Charles Bowden and Hans - J{\"u}rgen M{\"o}ller and Martin Bohus and Sophia Frangou and Waldemar Greil and Joseph R. Calabrese},
  journal={Journal of affective disorders},
  year={2009},
  volume={115 3},
  pages={466-70}
}
BACKGROUND Preliminary evidence suggests that the polarity of relapse/recurrence (depressive vs. hypomanic/manic/mixed) in bipolar patients on lithium might be related to serum lithium levels. METHODS Polarity of episodes in 64 bipolar-I patients on lithium monotherapy during a prospective 18-month maintenance trial was predicted from (a) intra-individual oscillations of lithium levels over time and from (b) absolute lithium levels preceding relapse/recurrence. RESULTS On an individual… CONTINUE READING