Is the pial microvessel a good model for blood-brain barrier studies?

@article{Allt1997IsTP,
  title={Is the pial microvessel a good model for blood-brain barrier studies?},
  author={G. Allt and John G Lawrenson},
  journal={Brain research. Brain research reviews},
  year={1997},
  volume={24 1},
  pages={67-76}
}
Pial microvessels have commonly been used as model systems for studying blood-brain barrier (BBB) properties instead of cerebral cortical microvessels. Since pial microvessels are relatively accessible they have been especially employed in electrophysiological and pharmacological studies. Measurements of electrical resistance across endothelial cells (EC) as a measure of their barrier properties have been made exclusively from pial microvessels in in vivo BBB studies. Similarly the observed… CONTINUE READING