Is the non-sentinel lymph node compartment the next site for melanoma progression from the sentinel lymph node compartment in the regional nodal basin?

@article{RiosCantu2017IsTN,
  title={Is the non-sentinel lymph node compartment the next site for melanoma progression from the sentinel lymph node compartment in the regional nodal basin?},
  author={Andrei Rios-Cantu and Ying Lu and Victor Melendez-Elizondo and Michael Yen-Minn Chen and Alejandra Gutierrez-Range and Niloofar Fadaki and Suresh Thummala and Carla West-Coffee and James Cleaver and Mohammed Kashani–Sabet and Stanley P. L. Leong},
  journal={Clinical & Experimental Metastasis},
  year={2017},
  volume={34},
  pages={345-350}
}
Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no additional positive lymph nodes. We hypothesize that the progression of disease from the SLN to the non-SLN compartment is orderly and is associated with the worsening of the disease status. Thus, the SLN and non-SLN compartments are biologically different in that cancer cells, in general… CONTINUE READING
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