Is the multifunctional Na(+)/H(+) exchanger isoform 1 a potential therapeutic target in cancer?

@article{Stock2012IsTM,
  title={Is the multifunctional Na(+)/H(+) exchanger isoform 1 a potential therapeutic target in cancer?},
  author={Christian M. Stock and Florian Timo Ludwig and Albrecht Schwab},
  journal={Current medicinal chemistry},
  year={2012},
  volume={19 5},
  pages={
          647-60
        }
}
The Na(+)/H(+) exchanger isoform 1 (NHE1) is a ubiquitously expressed transporter fulfilling a variety of cell physiological tasks. By importing Na(+) and exporting H(+), NHE1 contributes to regulatory volume increase and cytoplasmic pH homeostasis. In addition it anchors the cytoskeleton in the plasma membrane. NHE1 plays a critical role in mediating the progression of reperfusion injuries after ischemia. Moreover, it is upregulated and/or overexpressed in a number of tumour cells. In many… CONTINUE READING