Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.

@article{Tahara2006IsTM,
  title={Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.},
  author={Harunobu Tahara and Hiroyuki Kusuhara and Michihiro Chida and Eiichi Fuse and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 3},
  pages={1187-94}
}
The renal drug-drug interaction between famotidine (an H(2) receptor antagonist) and probenecid has not been reproduced in rats. We have proposed that this is caused by a species difference in the transport activity by human/rat organic anion transporter (OAT) 3 and the expression of organic cation transporter (OCT) 1 in the rodent kidney. Since monkey OATs (mkOATs) exhibit similar transport activities to human orthologs, it is hypothesized that in vivo studies in monkeys will allow a more… CONTINUE READING
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