Is the minimal model too minimal?

  title={Is the minimal model too minimal?},
  author={Andrea Caumo and Paolo Vicini and Professor C. Cobelli},
The intravenous glucose tolerance test (IVGTT: standard or modified with a tolbutamide or insulin injection) interpreted with the classic minimal model of glucose disappearance [1, 2] is a powerful non-invasire tool with which to investigate glucose metabolism in physiopathology studies. The model provides two metabolic indices measuring glucose effectiveness, Sc~ and insulin sensitivity, SI, in a single individual. S c and S I are composite parameters, i.e. they measure the net effect of… CONTINUE READING


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