Is the mTOR-signalling cascade disrupted in Schizophrenia?

  title={Is the mTOR-signalling cascade disrupted in Schizophrenia?},
  author={Anand Gururajan and Maarten van den Buuse},
  journal={Journal of neurochemistry},
  volume={129 3},
The mammalian target of rapamycin (mTOR) signalling cascade is involved in the intracellular regulation of protein synthesis, specifically for proteins involved in controlling neuronal morphology and facilitating synaptic plasticity. Research has revealed that the activity of the mTOR cascade is influenced by several extracellular and environmental factors that have been implicated in schizophrenia. Therefore, there is reason to believe that one of the downstream consequences of dysfunction or… CONTINUE READING