Is the incidence of aliphatic amine-induced occupational rhinitis and asthma underestimated?

  title={Is the incidence of aliphatic amine-induced occupational rhinitis and asthma underestimated?},
  author={Herv{\'e} Laborde-Cast{\'e}rot and Nicole Rosenberg and Patricia Dupont and Robert Garnier},
  journal={American journal of industrial medicine},
  volume={57 12},
BACKGROUND Amines, some of which are known to cause asthma, are frequently present in the work environment, but are rarely identified as being responsible for occupational rhinitis (OR) or asthma (OA). However, amine-induced OR/OA may be underreported. To discuss this hypothesis, we report a series of patients with positive amine-specific nasal provocation test (NPT). METHODS Review of the medical charts of 37 patients with OR (alone or associated with asthma), submitted to a NPT with an… 

Figures and Tables from this paper

Allergic contact dermatitis in two employees of an ethylene amine‐producing factory

Two process operators with allergic contact dermatitis caused by EDA working in the same company producing ethylene amines are presented.

Occupational rhinitis and occupational asthma: Association or progression?

Limited data support the notion that occupational rhinitis precedes the development of occupational asthma, particularly when high-molecular-weight (HMW) agents are involved.

Local allergic rhinitis: mechanisms, diagnosis and relevance for occupational rhinitis

The possibility of a local occupational Rhinitis should be considered in workers with a clear history of occupational rhinitis and negative immunological test, especially in the case of high molecular weight allergens.

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work‐related asthma and airway diseases, with increased knowledge gained over the past few years.

Occupational asthma caused by an epoxy amine hardener.

Exposure to epoxy hardeners containing polyfunctional amines should be considered as a potential cause of occupational asthma and Appropriate work hygiene measures should be implemented to minimize airborne exposure to these volatile compounds.

Machine learning-driven identification of early-life air toxic combinations associated with childhood asthma outcomes.

Several air toxic members of the combinations would not have been identified by single air toxic analyses, supporting the use of machine learning-based methods designed to detect combinatorial effects.

Rhinitis and Related Upper Respiratory Conditions



Piperazine-induced occupational asthma.

Tests of nonspecific bronchial reactivity with methacholine in six subjects with recent asthma showed hyperactivity in five, while tow subjects with earlier asthma did not have hyperactivity.

Quaternary ammonium compounds and occupational asthma

It is pointed out an as yet poorly known etiology of occupational asthma to quaternary ammonium compounds in hospital employees, which has been rarely reported so far, despite wide use of these products.

Occupational rhinitis and asthma due to EDTA-containing detergents or disinfectants.

This case series is the first report of EDTA-related respiratory disease, documented by a specific test, and a ban of spray preparations would be sufficient to prevent respiratory disease induced by EDTA inhalation, regardless of its mechanism.

Occupational asthma caused by inhalation of surfactant composed of amines.

The case of a male worker in the meat industry suffering from OA resulting from exposure to a surfactant agent used to clean the animal carcass before it is quartered is presented.

Asthma in chemical workers exposed to aliphatic polyamines.

The study indicated a very high risk of asthma and chronic airways disease and a need for stringent measures to protect the health of industrial workers exposed to aliphatic amines in Singapore.

Cleaning agents and asthma.

Cleaning workers are exposed to a large variety of cleaning products containing both irritants and sensitizers, as well as to common indoor allergens and pollutants, and the onset or aggravation of asthma in this group could be related to an irritant-induced mechanism or to specific sensitization.

Occupational asthma and occupational rhinitis: the united airways disease model revisited

Results are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.

Occupational asthma caused by ethanolamines

Persistence of the symptoms after exposure ended was a common feature of the three cases of occupational asthma caused by ethanolamines, and the diagnosis was based on work‐related symptoms and on a chamber challenge with the suspected agent.

Ethylenediamine-induced asthma.

Ethylenediamine released histamine in studies in vitro from the whole blood of patients as well as in those of 2 unexposed subjects, and the role of direct, histamine release in the pathogenesis of asthma has yet to be determined.

Diethanolamine‐induced occupational asthma, a case report

  • PiipariTuppurainen Nordman
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1998
Marked exposure through airways is uncommon in other than occupational settings where chemicals containing amino alcohols may be heated or vaporized, liberating free aminocohols into the ambient air.