Is the in-frame termination signal of the Escherichia coli release factor-2 frameshift site weakened by a particularly poor context?

Abstract

The synthesis of release factor-2 (RF-2) in bacteria is regulated by a high efficiency +1 frameshifting event at an in-frame UGA stop codon. The stop codon does not specify the termination of synthesis efficiently because of several upstream stimulators for frameshifting. This study focusses on whether the particular context of the stop codon within the… (More)

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