Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma?

@article{PlattsMills2005IsTH,
  title={Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma?},
  author={T. Platts-Mills and E. Erwin and P. Heymann and J. Woodfolk},
  journal={Allergy},
  year={2005},
  volume={60}
}
The hygiene hypothesis states that a reduced exposure to allergens in early life is solely implicated in the growing propensity for allergy sensitization. Important elements of the hypothesis include helminth infection, exposure to endotoxins, exposure to pets and growing up on a farm. However, the hygiene hypothesis alone does not provide an adequate explanation for the observed increase in allergic disease. For example, in North American inner cities, asthma is increasing among children who… Expand
160 Citations
The hygiene hypothesis: do we still believe in it?
  • B. Björkstén
  • Biology, Medicine
  • Nestle Nutrition workshop series. Paediatric programme
  • 2009
  • 47
Household chemicals, immune function, and allergy: A commentary
  • 6
Childhood Environment and Atopic Conditions, with Emphasis on Asthma in a Chilean Agricultural Area
  • 18
  • PDF
Too clean, or not too clean: the Hygiene Hypothesis and home hygiene
  • 227
  • PDF
Risk and protective factors for the development of childhood asthma.
  • 34
Latex Allergy and Sensitization in Cities: A Survey in a Population at Risk
  • 3
  • PDF
Living on a farm: impact on asthma induction and clinical course.
  • 153
Environmental pollutants and pediatric asthma
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
The role of domestic allergens.
  • 63
Indoor allergens and asthma: report of the Third International Workshop.
  • 670
  • Highly Influential
  • PDF
House dust mite exposure as a cause of asthma
  • 292
Effect of cat and dog ownership on sensitization and development of asthma among preteenage children.
  • 285
  • PDF
Effects of dog ownership and genotype on immune development and atopy in infancy.
  • 201
  • PDF
Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study.
  • 1,605
Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens.
  • 105
...
1
2
3
4
5
...