Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

@article{Fluhr2010IsTF,
  title={Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?},
  author={Joachim Wilhelm Fluhr and Peter M Elias and Manuel Man and Melanie Hupe and Clare Selden and John P. Sundberg and Erwin Tschachler and Leopold Eckhart and Theodora M. Mauro and Kenneth R. Feingold},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 8},
  pages={2141-4}
}
TO THE EDITOR Acidification of the surface of the stratum corneum (SC), the acid mantle, was initially thought to be important in the defense against infection. The growth of pathogenic microorganisms, such as Staphylococcus aureus and Streptococcus pyogenes, is inhibited by an acidic skin pH whereas the growth of resident (normal) skin flora is stimulated (Puhvel et al., 1975; Korting et al., 1990, 1992). However, recent studies have shown that acidification of the SC has additional functions… CONTINUE READING

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