Is the energy homeostasis system inherently biased toward weight gain?

@article{Schwartz2003IsTE,
  title={Is the energy homeostasis system inherently biased toward weight gain?},
  author={Michael J. Schwartz and Stephen Woods and Randy J Seeley and Gregory S Barsh and Denis G. Baskin and Rudolph L. Leibel},
  journal={Diabetes},
  year={2003},
  volume={52 2},
  pages={232-8}
}
We describe a model of energy homeostasis to better understand neuronal pathways that control energy balance and their regulation by hormonal signals such as insulin and leptin. Catabolic neuronal pathways are those that both reduce food intake and increase energy expenditure (e.g., melanocortin neurons in the hypothalamic arcuate nucleus) and are stimulated by input from insulin and leptin. We propose that in the basal state, catabolic effectors are activated in response to physiological… CONTINUE READING