Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

@article{Lapauw2007IsTE,
  title={Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?},
  author={Bruno Lapauw and Stefan Goemaere and Patricia Crabbe and Joel M. Kaufman and Johannes Ruige},
  journal={European journal of endocrinology},
  year={2007},
  volume={156 3},
  pages={
          395-401
        }
}
OBJECTIVE The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. DESIGN We performed cross-sectional analyses using data from a 4-year follow-up study in community-dwelling men aged 75-89 years (n=159). METHODS Body composition was assessed by… CONTINUE READING

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