Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?


Mutations in components of the Wnt pathway contribute to the aberrant activation of the bcatenin/T-cell factor-4 (TCF-4) complex and initiate most colorectal cancers. Upon its activation, the b-catenin/TCF-4 complex induces the expression of target genes such as c-MYC, cyclin-D1 and EPHB receptors. EphB receptors are receptor tyrosine kinases (RTKs) that… (More)
DOI: 10.1136/gut.2007.131540


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