Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale.

@article{Platt2001IsTC,
  title={Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale.},
  author={Nick Platt and Siamon Gordon},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 5},
  pages={649-54}
}
The class A macrophage scavenger receptor (SR-A) is the prototypic member of an expanding family of membrane receptors collectively termed scavenger receptors (SRs) (1–3). Receptors of this group recognize a number of ligands, including chemically modified or altered molecules and, in particular, the modified lipoproteins that are pertinent to the development of vascular disease. As shown in Table 1, all characterized SR-A ligands are polyanionic, although many polyanions fail to bind SR-A… CONTINUE READING