Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?

@article{Zalba2001IsTB,
  title={Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?},
  author={Guillermo Zalba and F J Beaumont and Gorka San Jos{\'e} and Ana Fortu{\~n}o and Mar{\'i}a Antonia Fortu{\~n}o and J M Olivares D{\'i}ez},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2001},
  volume={16 Suppl 1},
  pages={2-5}
}
BACKGROUND Increases in oxidant stress, i.e. excessive production of superoxide anion (O2(.-)), have been reported in different models of hypertension. This study was designed to test the hypothesis that increased O2(.-) production, more than diminished nitric oxide (NO) generation, plays a critical role in endothelial dysfunction present in spontaneously hypertensive rats (SHR). METHODS The study was performed in 30-week-old normotensive Wistar-Kyoto rats (WKY) and SHR. In addition, 16-week… CONTINUE READING

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