Is the answer for Parkinson disease already in the medicine cabinet?

@article{Bower2011IsTA,
  title={Is the answer for Parkinson disease already in the medicine cabinet?},
  author={James Howard Bower and Beate R Ritz},
  journal={Neurology},
  year={2011},
  volume={76},
  pages={854 - 855}
}
There have been an increasing number of publications in support of the inflammatory hypothesis of Parkinson disease (PD). Proinflammatory cytokines and microglia occur in human PD brains,1,2 and inflammation may initiate a chain reaction leading to neuronal death.3 Cyclooxygenase inhibitors provide neuroprotection in animal models of PD.4 Nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of developing another neurodegenerative disease, Alzheimer disease.5 A recent meta-analysis of… Expand
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Modulating Microglia Activity with PPAR-γ Agonists: A Promising Therapy for Parkinson’s Disease?
TLDR
Current evidence in support of the beneficial effect of targeting peroxisome-proliferator-activated receptor (PPAR)-γ to achieve neuroprotection in Parkinson’s disease is reviewed. Expand
Pesticide-induced Immunotoxicity May Underlie Synergistic Gene-environment Interactions that Increase Parkinson's Disease Risk for High-risk Genotype Individuals at rs3129882 in the HLA-DRA Gene
TLDR
A clear understanding of how the immune system plays a role in this and other neurodegenerative disorders will be critical for successful development of disease biomarkers, and therapeutic interventions to delay or ameliorate the course of the disease. Expand
Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study
TLDR
Novel findings suggest that the MHC-II locus may increase susceptibility to PD through presentation of pathogenic, immunodominant antigens and/or a shift toward a more pro-inflammatory CD4+ T-cell response in response to specific environmental exposures, such as pyrethroid exposure through genetic or epigenetic mechanisms that modulate M HC-II gene expression. Expand
Can Ibuprofen Reduce Parkinson Disease Risk
Increasing evidence suggests that inflammation may play a role in neurodegenerative conditions like Parkinson disease (PD) and that reducing

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