Is the adrenal angiotensin receptor angiotensin II--or angiotensin III like?

@article{Braley1983IsTA,
  title={Is the adrenal angiotensin receptor angiotensin II--or angiotensin III like?},
  author={L M Braley and A I Menachery and Rocky Underwood and Gordon H. Williams},
  journal={Acta endocrinologica},
  year={1983},
  volume={102 1},
  pages={116-21}
}
In order to determine whether the adrenal receptor is primarily directed at angiotensin II (AII) or angiotensin III (AIII) the following in vitro experiments were performed examining aldosterone responsiveness in isolated glomerulosa cells. 1) Cells exposed to increasing doses (2.4 X 10(-10)M - 2.4 X 10(-6)M) of AII or AIII were found to be significantly more responsive to AII (AII's ED50 was 6.3 X 10(-10) M vs AIII's 4.6 X 10(-9)M P less than 0.001). 2) Octapeptide analogues (Sar1 Ala8 and… CONTINUE READING