Is the acute NMDA receptor hypofunction a valid model of schizophrenia?

  title={Is the acute NMDA receptor hypofunction a valid model of schizophrenia?},
  author={Albert Adell and Laura Jim{\'e}nez-S{\'a}nchez and Xavier L{\'o}pez-Gil and Tamara Rom{\'o}n},
  journal={Schizophrenia bulletin},
  volume={38 1},
Several genetic, neurodevelopmental, and pharmacological animal models of schizophrenia have been established. This short review examines the validity of one of the most used pharmacological model of the illness, ie, the acute administration of N-methyl-D-aspartate (NMDA) receptor antagonists in rodents. In some cases, data on chronic or prenatal NMDA receptor antagonist exposure have been introduced for comparison. The face validity of acute NMDA receptor blockade is granted inasmuch as… CONTINUE READING
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