Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?

@article{Vincent2015IsTP,
  title={Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?},
  author={John B Vincent},
  journal={Biological Trace Element Research},
  year={2015},
  volume={166},
  pages={7-12}
}
  • J. Vincent
  • Published 2015
  • Chemistry, Medicine
  • Biological Trace Element Research
Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diabetes. The mode of action of Cr(III) at a molecular level is still an area of active debate; however, the movement of Cr(III) in the body, particularly in response to changes in… Expand
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  • Medicine, Chemistry
  • The Journal of nutrition
  • 2017
Nearly 60 y ago, chromium, as the trivalent ion, was proposed to be an essential element, but the results of new studies indicate that chromium currently can only be considered pharmacologicallyExpand
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Ch Chromium(III)-transferrin was crystallized in the presence of the synergistic anion malonate and represents the first crystal structure of a Cr( III)-containing protein that binds Cr(III) as part of its physiological function. Expand
Effect of chromium on bioenergetics and leukocyte dynamics following immunoactivation in lactating Holstein cows.
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