Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?

  title={Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?},
  author={John B. Vincent},
  journal={Biological Trace Element Research},
  • J. Vincent
  • Published 17 January 2015
  • Biology
  • Biological Trace Element Research
Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diabetes. The mode of action of Cr(III) at a molecular level is still an area of active debate; however, the movement of Cr(III) in the body, particularly in response to changes in… 
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  • Biology
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2014
The Bioinorganic Chemistry of Chromium
chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(iii) and hexavalent chromium(Vi). Although chromium(Vi) is a well known human toxin and potential
The biochemistry of chromium.
  • J. Vincent
  • Biology, Chemistry
    The Journal of nutrition
  • 2000
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The binding of trivalent chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transfer of chromium from transferrin and chromium picolinate to LMWCr
Chromium is readily transferred from transferrin to apoLMWCr at near neutral pH and reduction of the chromic center of Cr(pic)3 may be required for the supplement to release chromium; thus, release of chromium is related to a mechanism by which Cr (pic) 3 may generate hydroxyl radicals in cells.
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