Is the NBN gene mutation I171V a potential risk factor for malignant solid tumors in children?


NBN gene is considered as one of the low-to-moderate cancer susceptibility gene. At least 4 germline NBN mutations have been found in several malignancies in adults. In our studies, we observed the high incidence of germline mutation I171V of NBN gene in breast, colorectal, larynx cancer, and in multiple primary tumors. In this study, we would like to… (More)
DOI: 10.1097/MPH.0b013e3181faf886


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