Is the MDI doomed to extinction?

  title={Is the MDI doomed to extinction?},
  author={S. W. Epstein},
  volume={103 5},
I s the very successful brainchild of a 9-year-old asthmatic patientt doomed to extinction? In 1956,2 the chiorofluorocarbon (CFC)-propelled metered dose inhaler (MDI) was introduced to the world as a result of a suggestion from this young child. The growth in sales of M DIs, for the purpose of administering drugs directly to the upper and lower airways, has been impressive. Currently, the MDI is used in vast quantities around the world to deliver various drugs to the airways. It is a most… Expand
5 Citations
Efficacy of nebulized budesonide in treatment of severe infantile asthma: a double-blind study.
Nebulized budesonide (1 mg twice daily) is a well-tolerated and efficient treatment for severe infantile asthma and should improve and modify the treatment of infants with severe asthma. Expand
Therapeutic Controversies in the Treatment of Asthma
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M monitoring for adverse effects and the use of techniques to minimize systemic absorption (spacers and mouth rinsing) are recommended when high-dose inhaled glucocorticoid therapy is used. Expand
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The clinical experience with aerosol therapy during mechanical ventilation is reviewed and recommendations for therapeutic agents commonly used in this setting are formulated. Expand
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Bei personeller Trennung von Unternehmenseigentumern und -fuhrung treten im Wirtschaftsleben Prinzipal-Agent-Beziehungen auf, die zwar vielfaltig, doch in unterschiedlichen Landern grundsatzlichExpand
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Questions as to the use of pressurized aerosol inhalers were asked of 130 persons presenting for routine pulmonary function studies who had used such a device in the previous year and there were significant differences in performance according to referral diagnosis and regularity of use of inhalers. Expand
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Aerosols play an important role in the treatment of various forms of respiratory disease, with bronchodilators for the therapy of asthma being particularly important and the rate of removal of insoluble radioaerosols deposited in the lungs may be used as an index of mucociliary transport. Expand
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