Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index

@article{Boardman2013IsTG,
  title={Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index},
  author={Jason D. Boardman and Benjamin W Domingue and Casey L. Blalock and Brett C. Haberstick and Kathleen Mullan Harris and Matthew B Mcqueen},
  journal={Demography},
  year={2013},
  volume={51},
  pages={119-139}
}
This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS). We use completed college education as our environmental measure and estimate the interactive effect of genotype and education on body mass index (BMI) using 260,402 single-nucleotide polymorphisms (SNPs). Our results highlight the sensitivity of parameter estimates obtained from GWAS models and the difficulty of framing genome… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 66 references

Social environment, genes, and aggression: Evidence supporting the differential susceptibility perspective

  • R. L. Simons, M. K. Lei, S.R.H. Beach, G. H. Brody, R. A. Philibert, F. X. Gibbons
  • American Sociological Review,
  • 2011
Highly Influential
7 Excerpts

Social environmental and genetic influences on obesity and obesity promoting behaviors: Fostering research integration

  • M. S. Faith, T.V.E. Kral
  • Institute of Medicine (U.S.) Committee on…
  • 2006
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…