Is the EQ–5D fit for purpose in mental health?

  title={Is the EQ–5D fit for purpose in mental health?},
  author={John E. Brazier},
  journal={British Journal of Psychiatry},
  pages={348 - 349}
  • J. Brazier
  • Published 1 November 2010
  • Medicine, Psychology
  • British Journal of Psychiatry
Summary The EQ–5D is a widely used questionnaire for calculating quality-adjusted life-years (QALYs) for assessing cost-effectiveness in healthcare. It reflects the impact of common mental health conditions such as mild to moderate depression but seems to be more problematic for use in people with psychotic and severe and complex nonpsychotic disorders. 

Using generic preference-based measures in mental health: psychometric validity of the EQ-5D and SF-6D

EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems with some confidence and in schizophrenia, a preference-based measure focused on the impact of mental health should be considered.

How Valid and Responsive Are Generic Health Status Measures, such as EQ-5D and SF-36, in Schizophrenia? A Systematic Review

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Comparison of capability and health-related quality of life instruments in capturing aspects of mental well-being in people with schizophrenia and depression

Assessing outcomes in terms of capabilities for people with schizophrenia and depression provided more relevant, mental health-specific information than the EQ-5D-5L or the EQ -VAS.

The derivation of a preference-based measure for people with common mental health problems from the Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM)

The CORE-6D preference-based index will enable cost-utility analysis of mental health interventions using existing and prospective Core-OM datasets and can be useful for the derivation of PBMs from other instruments with highly correlated dimensions.

Does the EQ-5D capture the effects of physical and mental health status on life satisfaction among older people? A path analysis approach

The EQ-5D does not adequately capture the effects of anxiety and depression on LS among older adults, suggesting that it may lead to inaccurate assessments of the effectiveness of interventions in this cohort.

Using preference based measures in mental health conditions: The psychometric validity of the EQ-5D and SF-6D

EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems and personality disorders with some confidence and in schizophrenia, the measurement of quality of life may be improved by developing a condition-specific preference based measure.

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Mapping algorithms can adequately predict EQ-5D-5L utilities from scores on DASS-21 and K-10, which enables disease-specific data from clinical trials to be applied for estimating outcomes in terms of quality-adjusted life years for use in economic evaluations.

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Does Assessing Outcomes in Terms of Capability for Schizophrenic Patients with Depression Provide more Information Than use of the NICE Recommended QALY? - An Empirical Comparison of the OxCAP-MH, ICECAP-A and EQ-5D-5L Instruments

Assessing outcomes in terms of capability for schizophrenic patients with depression provide more information than use of the NICE recommended QALY, and OxCAP-MH and ICECAP-A show similar construct validity in severely ill mental health patients within the capability framework.

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It is proposed that this variable may be associated with compromised functioning prior to the onset of psychosis, and may also have an impact on an individual's adjustment to psychosis after treatment is initiated.



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Subjective loss of QoL associated with psychotic disorders may be smaller than objective loss of functioning suggests, and the EQ–5D is problematic as an outcome measure in psychotic disorders.

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The proposed methodology resulted in the development of CORE-6D, a 2-dimensional health state description system consisting of a unidimensionally-behaving 5-item emotional component and a physical symptom item that will enable calculation of quality adjusted life years in people with common mental health problems.

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