Is the C-terminal Region of Bradykinin the Binding Site of Polyphenols?

  title={Is the C-terminal Region of Bradykinin the Binding Site of Polyphenols?},
  author={Tristan Richard and Jacqueline Delaunay and Jean-Michel M{\'e}rillon and Jean Pierre Monti},
  journal={Journal of Biomolecular Structure and Dynamics},
  pages={379 - 385}
Abstract Bradykinin is a bioactive hormone involved in a variety of physiological processes. In various solvents, this peptide adopts β-turn structures. The C-terminal turn is a structural feature for the receptor affinity of agonists and antagonists while the N-terminal turn might be important for antagonistic activities. Polyphenols like dimeric proanthocyanidin B3 interact with the peptide. Thus to investigate the effects of polyphenols on bradykinin activity and structure, we studied the… 

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