Corpus ID: 11216430

Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?

@article{Mundo2000IsT5,
  title={Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?},
  author={E. Mundo and Margaret A. Richter and F Sam and Fabio Macciardi and James L. Kennedy},
  journal={The American journal of psychiatry},
  year={2000},
  volume={157 7},
  pages={
          1160-1
        }
}
  • E. Mundo, Margaret A. Richter, +2 authors James L. Kennedy
  • Published in
    The American journal of…
    2000
  • Medicine
  • OBJECTIVE Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)(1Dbeta) autoreceptor, modifies OCD symptoms. The aim of this study was to investigate the presence of linkage disequilibrium between the 5-HT(1Dbeta) receptor gene, which has a variant caused by a silent G to C substitution at nucleotide 861 of… CONTINUE READING

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