Is tDCS a potential first line treatment for major depression?

  title={Is tDCS a potential first line treatment for major depression?},
  author={Rachel D. Woodham and Rachael M Rimmer and J. Mutz and Cynthia H. Y. Fu},
  journal={International Review of Psychiatry},
  pages={250 - 265}
Abstract Transcranial direct current stimulation (tDCS) is a novel treatment option for major depression which could be provided as a first-line treatment. tDCS is a non-invasive form of transcranial stimulation which changes cortical tissue excitability by applying a weak (0.5–2 mA) direct current via scalp electrodes. Anodal and cathodal stimulation leads to depolarisation and hyperpolarisation, respectively, and cumulative effects are observed with repeated sessions. The montage in… 

Intervention is a better predictor of tDCS mind-wandering effects than subjective beliefs about experimental results

Results support objective intervention as the strongest predictor of stimulation effects on mind-wandering when 2mA vs sham was examined, over and above that of subjective intervention.

Effectiveness of transcranial direct current stimulation over dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness: A systematic review and meta-analysis

Background Transcranial direct current stimulation (tDCS) has been widely studied for treatment of patients with prolonged disorders of consciousness (PDOC). The dorsolateral prefrontal cortex



Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial

Findings confirm earlier reports of the antidepressant efficacy and safety of tDCS and Vigilance for mood switching is advised when administering tDCS to individuals with bipolar disorder.

Acute working memory improvement after tDCS in antidepressant-free patients with major depressive disorder

Transcranial Direct Current Stimulation for the Treatment of Depression: a Review of the Candidate Mechanisms of Action

Baseline measures of working memory and letter fluency may aid patient selection in future clinical trials of tDCS, and reduction of stress responsivity may be a key mechanism of action for tDCS in clinical groups and merits further investigation, acutely and post-treatment.

Is sertraline plus transcranial direct current stimulation the future of effective depression treatment?

The main results are that the results of the combination of pharmacotherapy and transcranial direct current stimulation protocols for treating major depressive disorder are pointing toward a relevant impact on the treatment of the disease.

Physiology of Transcranial Direct Current Stimulation

An overview of the current knowledge available regarding physiological mechanisms of tDCS, spanning from acute regional effects, over neuroplastic effects to its impact on cerebral networks is given.

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability.

It is suggested that polarity-driven alterations of resting membrane potentials represent the crucial mechanisms of the DC-induced after-effects, leading to both an alteration of spontaneous discharge rates and to a change in NMDA-receptor activation.