Is switching antidepressants following early nonresponse more beneficial in acute-phase treatment of depression?: a randomized open-label trial.

Abstract

RATIONALE Treatment guidelines for major depressive disorder (MDD) recommend a continuous use of antidepressants for several weeks, while recent meta-analyses indicate that antidepressant efficacy starts to appear within 2 weeks and early treatment nonresponse is a predictor of subsequent nonresponse. OBJECTIVES We prospectively compared 8-week outcomes… (More)
DOI: 10.1016/j.pnpbp.2011.08.008

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