Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression.

@article{Simpson1998IsSD,
  title={Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression.},
  author={Sallie W Simpson and Robert C. Baldwin and Alan Jackson and Alistair S. Burns},
  journal={Psychological medicine},
  year={1998},
  volume={28 5},
  pages={1015-26}
}
BACKGROUND Late-life depression is associated with increased subcortical white matter hyperintensities. There is some evidence that they are associated with a poorer response to acute treatment. Neurological signs and neuropsychological dysfunction are further evidence of abnormalities in the brain, but they have not been studied in relation to therapy resistance. METHODS A prospective study of 24 normal controls and 75 consecutive elderly (aged 65 to 85) patients with DSM-III-R major… CONTINUE READING
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