Is structural remodeling of fibrillated atria the consequence of tissue hypoxia?

  title={Is structural remodeling of fibrillated atria the consequence of tissue hypoxia?},
  author={Hiroshi Ogi and Yukiko Nakano and Shumpei Niida and Keigo Dote and Yukoh Hirai and Kazuyosi Suenari and Yukiji Tonouchi and Noboru Oda and Yuko Makita and Shigeyuki Ueda and Kenta Kajihara and Katsuhiko Imai and Taijro Sueda and Kazuaki Chayama and Yasuki Kihara},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={74 9},
BACKGROUND Matrix metalloproteinases (MMPs) play an important role in degradation of the extracellular matrix of injured tissue. MMP-9 expression increases in fibrillating atrial tissue; however, the mechanism for this increase has not been clarified. METHODS AND RESULTS Changes in the expression of vascular endothelial growth factor (VEGF), VEGF receptors, and hypoxia-induced transcription factor-1alpha (HIF-1alpha) in fibrillating atrial tissue were investigated. Atrial tissue samples were… CONTINUE READING
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