Is single fraction 15 Gy the preferred high dose-rate brachytherapy boost dose for prostate cancer?

@article{Morton2011IsSF,
  title={Is single fraction 15 Gy the preferred high dose-rate brachytherapy boost dose for prostate cancer?},
  author={Gerard C. Morton and Andrew Loblaw and Patrick C F Cheung and Ewa Szumacher and Manraj Chahal and Cyril Danjoux and Hans T. Chung and Andrea Deabreu and Alexandre Mamedov and Liying Zhang and R. Sankreacha and {\'E}ric Vigneault and Colvin D Springer},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2011},
  volume={100 3},
  pages={463-7}
}
BACKGROUND AND PURPOSE High dose-rate (HDR) brachytherapy is most commonly administered as a boost in two or more fractions combined with external beam radiotherapy (EBRT). Our purpose is to compare outcomes with a single fraction HDR boost to that with a standard fractionated boost in intermediate risk prostate cancer. MATERIALS AND METHODS Results of two sequential phase II clinical trials are compared. The Single Fraction protocol consists of 15 Gy HDR in one fraction followed by 37.5 Gy… CONTINUE READING