Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

@article{Andrews2015IsSA,
  title={Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response},
  author={Paul W. Andrews and Aadil Bharwani and Kyuwon Rosa Lee and Molly Fox and J. Anderson Thomson},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2015},
  volume={51},
  pages={164-188}
}
The role of serotonin in depression and antidepressant treatment remains unresolved despite decades of research. In this paper, we make three major claims. First, serotonin transmission is elevated in multiple depressive phenotypes, including melancholia, a subtype associated with sustained cognition. The primary challenge to this first claim is that the direct pharmacological effect of most symptom-reducing medications, such as the selective serotonin reuptake inhibitors (SSRIs), is to… Expand
A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance - A conceptual view.
TLDR
A theoretical framework is developed for understanding how adaptations to SSRIs that restore synaptic homeostasis may partially contribute to their hormetic effects and rodent models show that serotonin neurotransmission to specific forebrain regions is a necessary, but insufficient cause of depressive symptoms. Expand
From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder
TLDR
The evidence challenging the monoamine hypothesis is summarized and proposed that the antidepressant efficacy of SSRIs is not derived from elevated monoamine (5-HT, noradrenaline (NE), or dopamine (DA) concentration or monoamine neurotransmission. Expand
Managing epilepsy-associated depression: Serotonin enhancers or serotonin producers?
TLDR
The potential of various anti-inflammatory approaches such as selective cyclooxygenase-2 inhibitors, inflammatory cytokine inhibitors, and indoleamine 2,3-dioxygenase inhibitors pertaining to their serotonin restoring effects is discussed as possible therapy for treatment of depression in epilepsy. Expand
Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder
  • K. Murnane
  • Medicine, Psychology
  • Behavioural pharmacology
  • 2019
TLDR
It is proposed that stress, particularly stress related to danger and existential threats, increases the expression and function of 5-HT2A receptors and is argued that this is a neurobiological adaptation to promote learning and avoidance of danger in the future. Expand
Beyond a neurotransmitter: The role of serotonin in inflammation and immunity.
TLDR
The existing literature on what is known about the link between 5-HT and the immune system and the effects of 5- HT signaling on different cells of the peripheral immune system are summarized, with a particular focus on T cells. Expand
Computational Analysis of Therapeutic Neuroadaptation to Chronic Antidepressant in a Model of the Monoaminergic Neurotransmitter and Stress Hormone Systems
TLDR
A computational model of the monoaminergic neurotransmitter and stress-steroid systems that neuroadapts to chronic administration of combinations of antidepressant drugs and hormones by adjusting the strengths of its transmitter-system components (TSCs) revealed that therapeutic neuroadaptation to chronic SSRI is an overdetermined process that depends on multiple TSCs. Expand
Selective Serotonin Reuptake Inhibitor (SSRI) Efficiency, and Comparison to Alternative Antidepressant Treatments
TLDR
The analysis of data that was collected from an outpatient mental health private practice showed no advantage in effectiveness of SSRIs compared with other treatment options. Expand
Rapid-acting antidepressants: shared neuropharmacological mechanisms
TLDR
Novel evidence of a specific brain state characterized by slow EEG oscillations and the activation of molecular pathways implicated in rapid-acting antidepressant actions is provided, encouraging the investigation of cortical excitation and the subsequent homeostatic increase of slow EEGscillations as a fundamental basis of rapid- acting antidepressant treatments. Expand
The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models
TLDR
This chapter will focus on functions of TPH2 and describe the behavioral outcomes of its genetic deletion in rodents, a valuable model for several psychiatric diseases, such as autism and attention-deficit hyperactivity disorder. Expand
Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants.
TLDR
This study suggests that platelet 5- HT levels might respond to SSRI treatment, but this peripheral index is not a direct reflector of central 5-HT levels. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 542 REFERENCES
The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover
  • I. Branchi
  • Medicine, Psychology
  • Psychoneuroendocrinology
  • 2011
TLDR
The undirected susceptibility to change model predicts that an increase of serotonin levels, for instance induced through selective serotonin reuptake inhibitor (SSRI) administration, does not affect mood per se, but enhances neural plasticity and, thus, the effects of the environment on mood. Expand
Serotonin synthesis, release and reuptake in terminals: a mathematical model
TLDR
A mathematical model of serotonin synthesis, release, and reuptake in a single serotonergic neuron terminal is constructed and it is found that dopamine synthesis is insensitive to the availability of tyrosine but serotonin synthesis is sensitive to theavailability of tryptophan. Expand
Handbook of the behavioral neurobiology of serotonin
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It isExpand
Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain
TLDR
It is demonstrated that chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain, and the regulation of 5-HT synthesis warrants consideration in efforts to develop novel antidepressant strategies. Expand
5-HT1A receptor function in major depressive disorder
TLDR
It is raised the possibility that 5-HT(1A) receptor dysfunction represents one potential mechanism underpinning MDD and other stress-related disorders. Expand
Serotonin in panic and anxiety disorders
Abstract Selective serotonin reuptake inhibitors (SSRIs) are largely used to treat several anxiety disorders. Nevertheless, despite being the focus of intensive research interest over the past 35Expand
The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms
TLDR
An overview of current developments in the field of serotonin (5-HT) hypothesis of depression, with an emphasis on cellular and molecular mechanisms, and how their unravelling opens new perspectives for future research is provided. Expand
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
TLDR
Altered levels in hippocampal 5-HT1A levels and in the MR/GR balance may be one of the mechanisms by which stress may trigger and/or maintain depressive episodes. Expand
Receptor sensitivity and the mechanism of action of antidepressant treatment. Implications for the etiology and therapy of depression.
TLDR
The effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function are evaluated to provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies ofAmine receptor function in patients. Expand
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Chronic stressful life events are risk factors for developing major depression, the pathophysiology of which is strongly linked to impairments in serotonin (5-HT) neurotransmission. Exposure toExpand
...
1
2
3
4
5
...