Is screening for thrombophilia cost-effective?

@article{Wu2007IsSF,
  title={Is screening for thrombophilia cost-effective?},
  author={Olivia Wu and Ian A. Greer},
  journal={Current Opinion in Hematology},
  year={2007},
  volume={14},
  pages={500–503}
}
  • O. Wu, I. Greer
  • Published 2007
  • Medicine
  • Current Opinion in Hematology
Purpose of reviewThe aim of this review was to examine the current evidence on the cost-effectiveness of screening for thrombophilia. Recent findingsFew studies have attempted to evaluate the cost-effectiveness of screening for thrombophilia. The direct medical costs associated with screening, in order to detect one case of thrombophilia and indeed to prevent a subsequent venous thromboembolism, are high. Irrespective of patient groups, selective history-based thrombophilia screening has been… Expand
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TLDR
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TLDR
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References

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Screening for thrombophilia in high‐risk situations: a meta‐analysis and cost‐effectiveness analysis
TLDR
Selective thrombophilia screening based on previous personal and/or family history of venous thromboembolism was more cost‐effective than universal screening in all the patient groups evaluated. Expand
Pros and cons of thrombophilia testing: pros
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  • Medicine
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Thrombophilia screening helps to decide on the usefulness of primary prophylaxis in the presence of transient risk factors in asymptomatic relatives of thrombosis patients diagnosed with thromBophilia. Expand
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TLDR
With the developing interest in the role of prothrombotic abnormalities in thrombosis risk, haematologists and other clinicians have come under pressure to initiate laboratory tests on an increasing number of patients and there are several important issues relevant to the clinical utility and cost effectiveness. Expand
Cost-effectiveness of screening for the factor V Leiden mutation in pregnant women
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It is suggested that screening of pregnant women for the FVL mutation is not cost-effective and would result in prevention of less than one and three vascular events, respectively. Expand
Pros and cons of thrombophilia testing: cons
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  • Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 2003
TLDR
Widespread thrombophilia screening has been advocated in many clinical situations but particularly in women prior to starting a combined oral contraceptive pill or hormone replacement therapy and also during pregnancy, but whether indiscriminate generalized screening and the routine clinical practice of testing is necessary or helpful is considered. Expand
Laboratory testing for heritable thrombophilia: impact on clinical management of thrombotic disease
TLDR
It is now commonplace for a broad range of laboratory investigations to be used to determine the presence of heritable thrombophilia, as a genetic contribution can frequently be identified. Expand
Testing for thrombophilia: an evidence-based approach
TLDR
It is concluded that testing for acquired thrombophilic conditions should be considered in all cases of venousThrombosis, whereas testing for inherited thromBophilic Conditions is unlikely to be helpful. Expand
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TLDR
Screening for factor V Leiden mutation before prescribing combination oral contraceptives is not a cost-effective use of U.S. health care dollars. Expand
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TLDR
The present study confirms that extensive thrombophilic screening before OC treatment is not currently advisable and APCR assessment, however, seems to have a favorable cost-effectiveness ratio. Expand
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TLDR
Oral but not transdermal ERT is associated with risk of VTE in postmenopausal women, and data suggest that transder mal ERT might be safer than oral ERT with respect to thrombotic risk. Expand
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