Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection

@article{Lamont2011IsRW,
  title={Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection},
  author={K. Lamont and S. Somers and L. Lacerda and L. Opie and S. Lecour},
  journal={Journal of Pineal Research},
  year={2011},
  volume={50}
}
Abstract:  Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain unclear. Recent studies demonstrate the presence of melatonin in wine. We propose that melatonin, at a concentration found in red wine, confers cardioprotection against ischemia–reperfusion injury. Furthermore, we investigated whether both melatonin and resveratrol protect via the activation of the newly discovered survivor… Expand
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Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine.
TLDR
The novel findings suggest that the presence of melatonin in red wine contributes to the cardioprotective effect of chronic and moderate consumption of red wine against lethal I/R injuries. Expand
Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies
TLDR
The role of resveratrol and diabetic cardiac function is reviewed including a brief discussion on in vitro and in vivo studies as well as the original observations in diabetic rats. Expand
Role of toll‐like receptor 4 in melatonin‐induced cardioprotection
TLDR
Cardioprotection induced by melatonin is mediated byTLR4 to activate the SAFE pathway, and stimulation of TLR4 with LPS pretreatment to mice reduced myocardial infarct size of the hearts isolated from wild‐type animals but failed to protect the hearts isolate from TNFα receptor 2‐knockout mice or cardiomyocyte‐specific STAT3‐deficient mice. Expand
Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review
TLDR
The role of the melatonin receptors and events downstream of receptor activation, for example, the reperfusion injury salvage kinase (RISK), survivor activating factor enhancement and Notch pathways, the sirtuins, nuclear factor E2–related factor 2 (Nrf2) and translocases in the outer membrane (TOM70) will be discussed. Expand
Loss of Cardioprotection With Ischemic Preconditioning in Aging Hearts: Role of Sirtuin 1?
TLDR
Although Sirt 1 deacetylase activity is increased with age during ischemia/reperfusion, the data suggest that the loss of the cardioprotective effect of IPC in older animals is likely to be independent of SIRT 1. Expand
Melatonin as a protective agent in cardiac ischemia-reperfusion injury: Vision/Illusion?
TLDR
This review shall describe the various signaling pathways involved in salvaging the heart against ischemia-reperfusion injury through modulating inextricably interlinked pathways. Expand
Lowering the alcohol content of red wine does not alter its cardioprotective properties.
TLDR
The findings suggest that moderate and regular consumption of lower alcohol content wines may confer beneficial effects without the risks associated with traditional wines of higher alcohol content. Expand
Melatonin attenuates angiotensin II-induced cardiomyocyte hypertrophy through the CyPA/CD147 signaling pathway
TLDR
It is indicated that Ang II induces cardiomyocyte hypertrophy through the CyPA/CD147 signaling pathway and promotes ROS production, which can be blocked by melatonin pretreatment in a concentration-dependent manner, in cultured H9C2 cells and that Cy PA/CD 147 signaling pathway inhibition protects against Ang II-induced carduomyocytehypertrophy. Expand
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects
TLDR
Mitochondria, which play a central role in such complex processes within the cell as apoptosis, ATP‐production or oxidative stress, are centrally involved in many aspects of CR‐induced protection against ischaemic injury. Expand
High density lipoprotein / sphingosine-1-phosphate-induced cardioprotection : Role of STAT 3 as part of the SAFE pathway
High density lipoprotein (HDL) cholesterol has beneficial effects beyond its atheroprotective function in reverse cholesterol transport, including cardioprotection against ischemia reperfusion (IR)… Expand
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