Is prevalence of PBC underestimated in patients with systemic sclerosis?

  title={Is prevalence of PBC underestimated in patients with systemic sclerosis?},
  author={Gary L Norman and Andrzej Bialek and Susan Encabo and Bohdan S. Butkiewicz and Anna Wiechowska-Kozlowska and Marek Brzosko and Zakera Shums and Piotr Milkiewicz},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  volume={41 10},
BACKGROUND Clinically significant primary biliary cirrhosis occurs in 2.5% of patients with systemic sclerosis. Primary biliary cirrhosis-specific autoantibodies include anti-mitochondrial, anti-glycoprotein 210, and anti-sp100 antibodies. The majority of asymptomatic anti-mitochondrial-positive subjects express histological features of primary biliary cirrhosis. Early detection of primary biliary cirrhosis is important, as timely introduction of ursodeoxycholic acid may improve prognosis. The… CONTINUE READING