Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4?

@article{Amar1984IsPT,
  title={Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4?},
  author={Avraham Amar and Nurit Rubinstein and S Hacham-Zadeh and Oved Cohen and Tzeela Cohen and Chaim Brautbar},
  journal={Tissue antigens},
  year={1984},
  volume={23 1},
  pages={17-22}
}
Twenty-one Israeli Jewish pemphigus vulgaris (PV) patients were studied for the HLA-D lymphocyte defined determinants and the serologically defined antigens of the HLA-A, B, and DR series. HLA-D typing revealed that Dw10 is significantly associated with PV: 86% of patients vs 18% of controls carried Dw10, and DR4 was present in 86% of patients as compared to 38% in the controls. The most striking observation was that all Dw10 positive patients were also positive for DR4, and no other patient… CONTINUE READING