Is pindolol augmentation effective in depressed patients resistant to selective serotonin reuptake inhibitors? A systematic review and meta‐analysis

@article{Liu2015IsPA,
  title={Is pindolol augmentation effective in depressed patients resistant to selective serotonin reuptake inhibitors? A systematic review and meta‐analysis},
  author={Yiyun Liu and Xinyu Zhou and Dan Zhu and Jian-jun Chen and B. Qin and Yuqing Zhang and Xiao Wang and Deyu Yang and Hua-qing Meng and Qing-hua Luo and Peng Xie},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2015},
  volume={30},
  pages={132 - 142}
}
  • Yiyun Liu, Xinyu Zhou, P. Xie
  • Published 1 May 2015
  • Psychology, Medicine
  • Human Psychopharmacology: Clinical and Experimental
This systematic review and meta‐analysis was conducted to assess the use of pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitor (SSRI) therapy. 

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A case is reported of a 34-year-old lady with a 2-year history of resistant depression who responded to pindolol augmentation of sertraline. It also illustrates the use of sleep electroencephalogram

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TLDR
A double-blind, randomized, controlled 6-week study of pindolol augmentation of selective serotonin reuptake inhibitors (SSRIs) in depressed outpatients resistant to SSRI monotherapy finds that the efficacy of pINDolol in augmenting clinical response to SSRIs in treatment-resistant depressed patients is not supported.

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The present review briefly presents the results of placebo‐controlled double‐blind trials of pindolol augmentation of SSRIs in patients with major depression, and focuses on factors that may account for the variability of findings.

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A treatment-resistant depressed patient developed bipolar rapid cycling in response to pindolol augmentation of paroxetine, after failing to respond in any fashion to pindolol added to desipramine.

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This study failed to replicate the rapid and dramatic response to pindolol augmentation in treatment-resistant depressed patients.

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