Is peripheral blood or bone marrow a better source of stem cells for transplantation in cases of HLA-matched unrelated donors? A meta-analysis.

@article{Wu2015IsPB,
  title={Is peripheral blood or bone marrow a better source of stem cells for transplantation in cases of HLA-matched unrelated donors? A meta-analysis.},
  author={Sha Wu and Cheng Zhang and Xiaoying Zhang and Ya-qi Xu and Tian-xia Deng},
  journal={Critical reviews in oncology/hematology},
  year={2015},
  volume={96 1},
  pages={20-33}
}
BACKGROUND Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT). However, it has been controversial whether the use of PB or BM leads to a more favorable outcome of HSCT that involves unrelated HLA-matched donors. METHODS We searched PubMed and Medline for relevant articles. Risk ratio (RR) and 95% confidence intervals (CIs) were calculated for statistical analyses. RESULTS Twelve studies and 5589 patients were included in the… CONTINUE READING