Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.

@article{Venkatachalam2001IsPH,
  title={Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.},
  author={Sundaresan Venkatachalam and Stuart D. Tyner and Curtis R. Pickering and Sean Boley and Leslie Recio and John E. French and Lawrence A. Donehower},
  journal={Toxicologic pathology},
  year={2001},
  volume={29 Suppl},
  pages={147-54}
}
The p53 tumor suppressor gene has been shown to be critical in preventing cancer in humans and mice. We have generated and extensively characterized p53-deficient mice lacking one (p53+/-) or both (p53-/-) p53 alleles. The p53-deficient mice are much more susceptible to an array of different tumor types than their wild-type (p53+/+) littermates. The enhanced tumor susceptibility of the p53+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for… CONTINUE READING

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