Is oxytocin an ovarian hormone?

@article{Wathes1982IsOA,
  title={Is oxytocin an ovarian hormone?},
  author={D. Wathes and R. W. Swann},
  journal={Nature},
  year={1982},
  volume={297},
  pages={225-227}
}
Oxytocin is a nonapeptide hormone produced by the hypothalamus and released from the posterior pituitary. It is cleaved from a large molecular weight precursor which is synthesized in cell bodies of hypothalamic magnocellular neurones and then packaged into membrane-bound granules1. During axonal transport the precursor is cleaved to produce oxytocin and an oxytocin-related neurophysin. Apart from its established roles in lactation and labour, oxytocin is thought to be an important regulator of… Expand
Ovarian secretion of oxytocin is stimulated by prostaglandin
TLDR
It is shown that in sheep, the concentration of oxytocin in ovarian venous blood exceeds that in arterial blood, and it is found that ovarian secretion of Oxytocin is stimulated by a prostaglandin F2α analogue. Expand
Gonadal sources of the posterior pituitary hormones.
TLDR
Both oxytocin- and vasopressin-related neurophysins indicate that synthesis of these neuropeptides may occur in the testis, as well as the ovary, and the most exciting possibility is that these peptides may provide a local feedback control system on steroid biosynthesis within the gonad. Expand
Oxytocin Receptors in the Uterus
TLDR
It now seems clear, from data collected in several species, that oxytocin’s activity during pregnancy and labor depends more on the of myometrial cells than on the concentration of the hormone in the circulation. Expand
Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum
  • F. Stormshak
  • Biology, Medicine
  • Reproductive biology and endocrinology : RB&E
  • 2003
TLDR
A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented and evidence is presented for potential autocrine/paracrine actions of Oxytocin in regulating progesterone production by luteal and granulosa cells. Expand
Oxytocin in the Initiation of Labor
A single cell (magnocellular neuron) is responsible for synthesis, transport, and release of oxytocin. Oxytocin prohormone is synthesized in single neuronal cells of the supraoptic andExpand
Effects of gonadotropins, insulin and insulin-like growth factor I on ovarian oxytocin and progesterone production
TLDR
The data suggest that gonadotropins regulate oxytocin synthesis and release and that these effects are amplified by insulin or IGF-I acting via their own receptors. Expand
Chronic regulation of ovarian oxytocin and progesterone release by prostaglandins: opposite effects in bovine granulosa and early luteal cells.
  • C. McArdle
  • Biology, Medicine
  • The Journal of endocrinology
  • 1990
TLDR
The results reveal that the effects of prostaglandins on oxytocin release are dependent on both the developmental stage of the target tissue and on the presence of other regulators of cellular differentiation, and suggest that the increase in responsiveness to insulin and IGF-I, which appears to accompany luteinization in the cow, may be an effect of prostglandins produced locally during the peri-ovulatory period. Expand
Oxytocin, oxytocin-associated neurophysin, and prostaglandin F2 alpha concentrations in the utero-ovarian vein of pregnant and nonpregnant sheep.
TLDR
Pituitary and luteal release of oxytocin may, therefore, occur simultaneously and be controlled by a circulating factor in sheep and the suppression of uterine PGF2 alpha release during early pregnancy is not considered to result from a lack of stimulation by Oxytocin. Expand
CHAPTER 58 – Oxytocin: Synthesis, Secretion, and Reproductive Functions
This chapter focuses on the peptide hormone oxytocin and its reproductive functions. Oxytocin plays a highly integrated role in reproductive physiology and allows the hormone to control reproductiveExpand
Oxytocin: a paracrine hormone in the regulation of parturition?
TLDR
It is concluded that further clarification of this paracrine system within intrauterine tissues during late gestation could lead to more successful strategies for preventing or arresting preterm labour in women. Expand
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The results suggest that the endometrium is a target for Oxytocin, synthesis of PGF2alpha by the uterus may involve interaction between oxytocin and its endometrial receptors and ovarian steroids may influence uterine PG synthesis by regulating the availability of these receptors. Expand
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The results demonstrate that the increased concentrations of PGFM which are found during the period of luteal regression are not caused by increased peripheral concentrations of oxytocin. Expand
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Oxytocin was less effective in causing diestrual shortening when either atropine or reserpine was administered concurrently, and was completely ineffective in inducing precocious estrus in hysterectomized, but not in sham-operated, heifers. Expand
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